The podcast episode “Zooming in on nano-particle analysis” interviews Antje Biesemeier, Senior R&T Associate at LIST. She sheds light on the huge topic of nanoparticle analysis through the lens of a revolutionary focused-ion beam-based microscope developed at LIST, the MagSIMS. MagSIMS stands for focused ion beam-based high-resolution microscopy with integrated secondary ion mass spectrometry allowing in depth physico-chemical characterisation of materials and life science samples. A special focus of this podcast is led on the npSCOPE, a dedicated tool with MagSIMS capabilities that allows correlative investigation based on secondary electron imaging, SIMS and transmitted beam information analysis. Initially designed as part of an EU-funded project for the dedicated nanotoxicological analysis of metallic nanoparticles after in vitro and in vivo exposure, the tool is also successfully applied to a plethora of other research fields like batteries, electronics, soil and polymers.